Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8469209 | 1.00 | TSHR (0.50) | TSHRALDH1A1FDPSTDP1OPRM1 | |
| Bromide SCHEMBL5546691 | 1.00 | TSHR (0.50) | TSHRALDH1A1FDPSTDP1OPRM1 | |
| Bromide SCHEMBL5552303 | 1.00 | TSHR (0.50) | TSHRALDH1A1FDPSTDP1OPRM1 | |
| Bromide SCHEMBL8466601 | 0.96 | TSHR (0.44) | TSHRALDH1A1FDPSTDP1OPRM1 | |
| Bromide SCHEMBL6549989 | 0.96 | TSHR (0.44) | TSHRALDH1A1FDPSTDP1OPRM1 | |
| Bromide SCHEMBL5551153 | 0.96 | TSHR (0.44) | TSHRALDH1A1FDPSTDP1OPRM1 | |
| Bromide SCHEMBL5550558 | 0.96 | TSHR (0.44) | TSHRALDH1A1FDPSTDP1OPRM1 | |
| Bromide SCHEMBL5550949 | 0.96 | TSHR (0.44) | TSHRALDH1A1FDPSTDP1OPRM1 | |
| Bromide SCHEMBL8467090 | 0.96 | TSHR (0.44) | TSHRALDH1A1FDPSTDP1OPRM1 | |
| SCHEMBL5547751 | 0.94 | TSHR (0.46) | TSHRALDH1A1FDPSTDP1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6726905-B1 | LOWERING SERUM PHOSPHATE | GENZYME CORPORATION | 2004-04-27 | — | — | US | disclosed |