Bromide

Bromide

SCHEMBL6549989

Br.CCCCCCC(CCCCl)C(C)(C)N

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.44
ALDH1A1 P00352 1/20 0.44
FDPS P14324 2/20 0.38
TDP1 Q9NUW8 1/20 0.37
OPRM1 P35372 1/20 0.35
SPHK1 Q9NYA1 2/20 0.34
LMNA P02545 2/20 0.33
DNM1 Q05193 1/20 0.33
GRIK1 P39086 1/20 0.33
GRIK2 Q13002 1/20 0.33
CYP2D6 P10635 2/20 0.32
SMPD1 P17405 2/20 0.32
PLA2G1B P04054 1/20 0.32
PLA2G2A P14555 1/20 0.32
GMNN O75496 1/20 0.32
POLB P06746 1/20 0.32
THPO P40225 1/20 0.32
MTOR P42345 1/20 0.32
BLM P54132 1/20 0.32
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL8467090 1.00 TSHR (0.44) TSHRALDH1A1FDPSTDP1OPRM1
Bromide SCHEMBL5550558 1.00 TSHR (0.44) TSHRALDH1A1FDPSTDP1OPRM1
Bromide SCHEMBL5551153 1.00 TSHR (0.44) TSHRALDH1A1FDPSTDP1OPRM1
Bromide SCHEMBL5550949 1.00 TSHR (0.44) TSHRALDH1A1FDPSTDP1OPRM1
Bromide SCHEMBL8466601 1.00 TSHR (0.44) TSHRALDH1A1FDPSTDP1OPRM1
SCHEMBL5547751 0.98 TSHR (0.46) TSHRALDH1A1FDPSTDP1OPRM1
Bromide SCHEMBL5552303 0.96 TSHR (0.50) TSHRALDH1A1FDPSTDP1OPRM1
Bromide SCHEMBL5546691 0.96 TSHR (0.50) TSHRALDH1A1FDPSTDP1OPRM1
Bromide SCHEMBL8469209 0.96 TSHR (0.50) TSHRALDH1A1FDPSTDP1OPRM1
Bromide SCHEMBL6760465 0.96 TSHR (0.50) TSHRALDH1A1FDPSTDP1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1014999-B1 CATIONIC POLYMERS AS TOXIN-BINDING AGENTS GENZYME CORP (US) 2004-12-08 EP disclosed
US-6692732-B2 Administering cationic polymers to mammals to prevent poisons or antigens from microorganisms such as bacteria, viruses, fungi or parasites; deactivation GENZYME CORPORATION 2004-02-17 US disclosed
US-20040009145-A1 IONIC POLYMERS AS TOXIN-BINDING AGENTS GELTEX PHARMACEUTICALS, INC. 2004-01-15 US disclosed
US-6482402-B1 BACTERICIDE AND CATIONIC POLYMER GELTEX PHARMACEUTICALS, INC. 2002-11-19 US disclosed
US-20020114774-A1 Ionic polymers as toxin-binding agents GELTEX PHARMACEUTICALS, INC. 2002-08-22 US disclosed
US-6290947-B1 IN ONE EMBODIMENT, THE POLYMER IS A COPOLYMER COMPRISING A MONOMER HAVING A PENDANT AMMONIUM GROUP AND A HYDROPHOBIC MONOMER. GELTEX PHARMACEUTICALS, INC. 2001-09-18 US disclosed
EP-1014999-A1 CATIONIC POLYMERS AS TOXIN-BINDING AGENTS GELTEX PHARMACEUTICALS, INC. (US) 2000-07-05 EP disclosed
US-6007803-A ADMINISTERING TO MAMMAL A CATIONIC POLYMER TO INHIBIT PATHOGENIC TOXINS GELTEX PHARMACEUTICALS, INC. (US) 1999-12-28 US disclosed
US-5969090-A QUATERNIZED CROSSLINKED HYDROCARBON AMINE POLYMER GELTEX PHARMACEUTICALS, INC. (US) 1999-10-19 US disclosed
US-5900475-A MODIFIED POLYALLYLAMINE; ANTICHOLESTEROL AGENT GELTEX PHARMACEUTICALS, INC. (US) 1999-05-04 US disclosed
WO-1999015186-A1 CATIONIC POLYMERS AS TOXIN-BINDING AGENTS GELTEX PHARMACEUTICALS, INC. (US) 1999-04-01 WO disclosed
EP-0830390-A1 HYDROPHOBIC HETEROATOM-CONTAINING SEQUESTRANT FOR CHOLESTEROL DEPLETION GELTEX PHARMACEUTICALS, INC. (US) 1998-03-25 EP disclosed
WO-1996039449-A1 HYDROPHOBIC HETEROATOM-CONTAINING SEQUESTRANT FOR CHOLESTEROL DEPLETION GELTEX PHARMACEUTICALS, INC. (US) 1996-12-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020114774-A1 Ionic polymers as toxin-binding agents PIGS, ANTXR2, MSN TSHR 622/4885ALDH1A1 4693/4885FDPS 4038/4885
US-20040009145-A1 IONIC POLYMERS AS TOXIN-BINDING AGENTS PIGS, ANTXR2, MSN TSHR 622/4885ALDH1A1 4693/4885FDPS 4038/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.