SCHEMBL6764313

SCHEMBL6764313

O=C(CNCc1ccc(C2=NCCN2C(=O)O)cc1)CNC(=O)CN(C1CC1)S(=O)(=O)c1cccc(Cl)c1Cl

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
USP2 O75604 2/20 0.35
RORC P51449 1/20 0.34
ALDH1A1 P00352 5/20 0.33
TP53 P04637 2/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
F10 P00742 1/20 0.32
LMNA P02545 1/20 0.32
BDKRB1 P46663 2/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
CTSS P25774 1/20 0.31
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6763998 0.92 USP2 (0.36) USP2RORCALDH1A1TP53ALOX15
SCHEMBL5118182 0.89 BDKRB1 (0.36) RORCALDH1A1F10LMNABDKRB1
SCHEMBL5110842 0.87 BDKRB1 (0.34) RORCF10BDKRB1
SCHEMBL6764299 0.86 BDKRB1 (0.46) USP2RORCTP53ALOX15TSHR
SCHEMBL5111163 0.86 BDKRB1 (0.40) RORCALDH1A1F10BDKRB1
SCHEMBL6764171 0.85 KMT2A (0.32) ALDH1A1TP53LMNAMEN1KMT2A
SCHEMBL5111911 0.81 BDKRB1 (0.34) RORCALDH1A1BDKRB1MEN1KMT2A
SCHEMBL5124978 0.80 BDKRB1 (0.33) RORCALDH1A1F10LMNABDKRB1
SCHEMBL6761755 0.80 KMT2A (0.37) ALDH1A1TP53LMNAMEN1KMT2A
SCHEMBL6762507 0.80 DAGLA (0.33) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040063725-A1 Novel n(phenylsulphonyl)glycine derivatives and their therapeutic use LABORATORIES FOURNIER S.A. (FR) 2004-04-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040063725-A1 Novel n(phenylsulphonyl)glycine derivatives and their therapeutic use GLS, GLS2, GLRB USP2 2448/4885RORC 3349/4885ALDH1A1 2730/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.