Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.37 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30466554 | 1.00 | EGFR (0.48) | EGFRFGFR4PIK3CAPIK3CDRPS6KA5 | |
| SCHEMBL30466525 | 0.84 | EGFR (0.47) | EGFRFGFR4PIK3CAPIK3CDRPS6KA5 | |
| SCHEMBL8874014 | 0.78 | EGFR (0.58) | EGFRFGFR4PIK3CAPIK3CDTDO2 | |
| SCHEMBL7920056 | 0.76 | EGFR (0.47) | EGFRFGFR4PIK3CAPIK3CDTDO2 | |
| SCHEMBL6364161 | 0.76 | EGFR (0.57) | EGFRFGFR4PIK3CAPIK3CD | |
| SCHEMBL4147243 | 0.74 | EGFR (0.60) | EGFRFGFR4PIK3CAPIK3CDTDO2 | |
| SCHEMBL24558650 | 0.73 | ALDH1A1 (0.50) | EGFRRPS6KA5ALDH1A1 | |
| SCHEMBL3320194 | 0.71 | PDE4A (0.47) | EGFRALDH1A1 | |
| SCHEMBL30460888 | 0.71 | EGFR (0.43) | EGFRFGFR4PIK3CAPIK3CDRPS6KA5 | |
| SCHEMBL2611072 | 0.71 | EGFR (0.43) | EGFRFGFR4PIK3CAPIK3CDTDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723726-B1 | Protein tyrosine kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-04-20 | — | — | US | disclosed |
| EP-0912570-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2003-09-10 | — | — | EP | disclosed |
| EP-1304110-A2 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2003-04-23 | — | — | EP | disclosed |
| US-6174889-B1 | PROTEIN TYROSINE KINASE INHIBITORS RELATED TO BIOISOSTERES OF QUINOLINE AND QUINAZOLINE DERIVATIVES; ANTICARCINOGENIC AND -TUMOR AGENTS; PSORIASIS; RESTENOSIS; RHEUMATOID ARTHRITIS, AUTOIMMUNE DISEASE, ALLERGY, ASTHMA AND GRAFT REJECTION | GLAXO WELLCOME INC. | 2001-01-16 | — | — | US | disclosed |
| EP-0912570-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998002438-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1998-01-22 | — | — | WO | disclosed |