Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 9/20 | 0.67 |
| ▸ | CCR2 | P41597 | 9/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722275 | 0.94 | SIGMAR1 (0.56) | CXCR4CCR2MEN1CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL29045124 | 0.92 | CXCR4 (0.57) | CXCR4CCR2MEN1CHRM2CHRM1 | |
| SCHEMBL8236801 | 0.84 | HRH3 (0.64) | CXCR4CCR2HRH3LMNA | |
| SCHEMBL29490414 | 0.81 | CXCR4 (1.00) | CXCR4CCR2MEN1CHRM2CHRM1 | |
| Plerixafor SCHEMBL19038 | 0.81 | CXCR4 (1.00) | CXCR4CCR2MEN1CHRM2CHRM1 | |
| SCHEMBL5611617 | 0.81 | CXCR4 (1.00) | CXCR4CCR2MEN1CHRM2CHRM1 | |
| SCHEMBL9621226 | 0.80 | CXCR4 (0.94) | CXCR4CCR2MEN1CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL7612104 | 0.79 | CXCR4 (1.00) | CXCR4CCR2MEN1CHRM2CHRM1 | |
| Plerixafor SCHEMBL414153 | 0.79 | CXCR4 (1.00) | CXCR4CCR2MEN1CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL7610931 | 0.79 | CXCR4 (1.00) | CXCR4CCR2MEN1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686353-B1 | PREVENTING BLOOD MONOCYTES AND LYMPHOCYTES FROM INFILTRATING TISSUE | TEIJIN INTELLECTUAL PROPERTY CENTER LIMITED (JP) | 2004-02-03 | — | — | US | disclosed |
| EP-0914319-B1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LTD (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0914319-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997044329-A9 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | — | 1998-03-12 | — | — | WO | disclosed |
| WO-1997044329-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1997-11-27 | — | — | WO | disclosed |