⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676577 | 1.00 | — | — | |
| SCHEMBL811234 | 0.84 | — | — | |
| SCHEMBL811235 | 0.84 | — | — | |
| SCHEMBL9330650 | 0.78 | ALDH1A1 (0.35) | — | |
| SCHEMBL9330653 | 0.78 | ALDH1A1 (0.35) | — | |
| SCHEMBL11654422 | 0.77 | ALDH1A1 (0.32) | — | |
| SCHEMBL7171273 | 0.76 | GAA (0.48) | — | |
| SCHEMBL7171261 | 0.76 | GAA (0.48) | — | |
| SCHEMBL26713884 | 0.75 | TDP1 (0.30) | — | |
| Propane SCHEMBL17224456 | 0.75 | APEX1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957056-B2 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTIUTE FOR CANCER RESEARCH (US) | 2015-02-17 | — | — | US | disclosed |
| US-8835693-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-09-16 | — | — | US | disclosed |
| US-20140011844-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-01-09 | — | — | US | disclosed |
| US-8324284-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-12-04 | — | — | US | disclosed |
| US-8202911-B2 | Migrastatin analog compositions and uses thereof | CORNELL RESEARCH FOUNDATION, INC. (US) | 2012-06-19 | — | — | US | disclosed |
| US-20110281916-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110263653-A1 | MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-10-27 | — | — | US | disclosed |
| US-7943800-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-05-17 | — | — | US | disclosed |
| US-20090124662-A1 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2009-05-14 | — | — | US | disclosed |
| US-20070037852-A1 | Migrastatin analogs and uses thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-15 | — | — | US | disclosed |
| US-20070037783-A1 | Migrastatin analogs and uses thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-15 | — | — | US | disclosed |
| EP-1613603-A2 | MIGRASTATIN ANALOGS AND USES THEREOF | Sloan-Kettering Institute For Cancer Research (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2006001967-A2 | MIGRASTATIN ANALOGS IN THE TREATMENT OF CANCER | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2006-01-05 | — | — | WO | disclosed |
| EP-1608626-A1 | MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF | CORNELL RESEARCH FOUNDATION, INC. (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004087672-A1 | MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF | CORNELL RESEARCH FOUNDATION, INC. (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004087673-A2 | MIGRASTATIN ANALOGS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2004-10-14 | — | — | WO | disclosed |
| US-5292885-A | Pyranone, process for its preparation, its use in the preparation of a new pyridinone and a process for the preparation of same | ISOCHEM (FR) | 1994-03-08 | — | — | US | disclosed |