Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 14/20 | 0.80 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.80 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.80 |
| ▸ | CCR2 | P41597 | 1/20 | 0.80 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.80 |
| ▸ | BLM | P54132 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5734193 | 0.93 | SIGMAR1 (0.68) | CXCR4HRH3MEN1CHRM2CHRM1 | |
| SCHEMBL208118 | 0.93 | SIGMAR1 (0.68) | CXCR4HRH3MEN1CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL4467874 | 0.91 | CXCR4 (0.68) | CXCR4HRH3MEN1CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL2921947 | 0.91 | CXCR4 (0.68) | CXCR4HRH3MEN1CHRM2CHRM1 | |
| Plerixafor SCHEMBL19038 | 0.89 | CXCR4 (1.00) | CXCR4HRH3MEN1CHRM2CHRM1 | |
| SCHEMBL5611617 | 0.89 | CXCR4 (1.00) | CXCR4HRH3MEN1CHRM2CHRM1 | |
| Methylene Chloride SCHEMBL28377911 | 0.89 | SIGMAR1 (0.63) | CXCR4HRH3MEN1CHRM2CHRM1 | |
| SCHEMBL29490414 | 0.89 | CXCR4 (1.00) | CXCR4HRH3MEN1CHRM2CHRM1 | |
| Plerixafor SCHEMBL6889125 | 0.87 | CXCR4 (1.00) | CXCR4HRH3MEN1CHRM2CHRM1 | |
| Plerixafor SCHEMBL414153 | 0.87 | CXCR4 (1.00) | CXCR4HRH3MEN1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0096875-B1 | LITHIUM ALKOXIDE DIAMINES AS MODIFIERS FOR POLYMERIZATION OF DIENES USING LITHIUM-BASED INITIATORS | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1986-10-08 | — | — | EP | claimed |
| US-4401800-A | Lithium alkoxide diamines as modifiers for polymerization of dienes using lithium-based initiators | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1983-08-30 | — | — | US | claimed |
| EP-1757591-A1 | CINNAMIDE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2007-02-28 | — | — | EP | disclosed |
| US-6686353-B1 | PREVENTING BLOOD MONOCYTES AND LYMPHOCYTES FROM INFILTRATING TISSUE | TEIJIN INTELLECTUAL PROPERTY CENTER LIMITED (JP) | 2004-02-03 | — | — | US | disclosed |
| EP-0914319-B1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LTD (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0914319-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997044329-A9 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | — | 1998-03-12 | — | — | WO | disclosed |
| WO-1997044329-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1997-11-27 | — | — | WO | disclosed |
| US-5340811-A | Bronchodilator agent | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0471841-A1 | SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1992-02-26 | — | — | EP | disclosed |
| EP-0252670-B1 | 2-SUBSTITUTED ALKOXY-3-SUBSTITUTED-PYRAZINES | TOYO JOZO KABUSHIKI KAISHA (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-4599337-A | Antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivatives as active ingredient | EISAI CO., LTD. (JP) | 1986-07-08 | — | — | US | disclosed |
| US-4543254-A | Antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivatives as active ingredient | EISAI CO., LTD. (JP) | 1985-09-24 | — | — | US | disclosed |
| US-4493837-A | VASODILATORS, ANALGESICS, NEUROLEPTIC AGENTS | EISAI CO., LTD. (JP) | 1985-01-15 | — | — | US | disclosed |
| EP-0127182-A1 | 1-Phenylalkyl-4-(mercapto and carbamylthio)alkyl-piperazines and -homopiperazines and their use in the treatment of allergic diseases | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1984-12-05 | — | — | EP | disclosed |
| EP-0122488-A1 | Bis-(piperazinyl- or homopiperazinyl)-alkanes | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1984-10-24 | — | — | EP | disclosed |
| EP-0096875-A1 | Lithium alkoxide diamines as modifiers for polymerization of dienes using lithium-based initiators | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1983-12-28 | — | — | EP | disclosed |
| EP-0087810-A1 | Antiphlogistic/antipyretic/analgesic pharmaceutical compositions containing theophylline derivatives as active ingredient | Eisai Co., Ltd. (JP) | 1983-09-07 | — | — | EP | disclosed |
| US-4401800-A | Lithium alkoxide diamines as modifiers for polymerization of dienes using lithium-based initiators | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1983-08-30 | — | — | US | disclosed |
| EP-0023350-A1 | Theophylline derivatives, a process for the preparation of the same and a therapeutical composition | Eisai Co., Ltd. (JP) | 1981-02-04 | — | — | EP | disclosed |