Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759755 | 0.90 | MAPK1 (0.50) | IGF1RMAPK1PIK3CAMAPK8MAPK9 | |
| SCHEMBL5759348 | 0.87 | MAPK1 (0.53) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL6765135 | 0.86 | TP53 (0.50) | ABCG2PDE5AMAPK1PIK3CAMAPK8 | |
| SCHEMBL6762811 | 0.85 | ABCG2 (0.51) | ABCG2ABCC1MAPK1PIK3CAMAPK8 | |
| SCHEMBL5757913 | 0.85 | PIK3CA (0.54) | ABCG2ABCB1ABCC1MAPK1PIK3CA | |
| SCHEMBL5757875 | 0.82 | MAPK1 (0.61) | ABCG2MAPK1PIK3CAMAPK8MAPK9 | |
| SCHEMBL5760063 | 0.82 | AURKA (0.53) | ABCG2MAPK1PIK3CAMAPK8MAPK9 | |
| SCHEMBL6762843 | 0.81 | BCHE (0.56) | ABCG2ABCC1PDE5AROCK1ABL1 | |
| SCHEMBL5758071 | 0.80 | MAP4K4 (0.52) | PDE5AMAPK1PIK3CAMAPK8MAPK9 | |
| SCHEMBL4697024 | 0.79 | MAPK1 (0.56) | MAPK1PIK3CAMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727252-B1 | THE SERINE/THREONINE KINASE FAMILY INCLUDES MEMBERS THAT REGULATE CELL GROWTH, MIGRATION, DIFFERENTIATION, GENE EXPRESSION, MUSCLE CONTRACTION, GLUCOSE METABOLISM, CELLULAR PROTEIN SYNTHESIS, AND REGULATION OF THE CELL CYCLE | ZENTARIS AG (DE) | 2004-04-27 | — | — | US | disclosed |
| US-6180631-B1 | PREVENTING AND TREATING SERINE/THREONINE PROTEIN KINASE-RELATED ABNORMAL CONDITIONS IN MAMMALS ASSOCIATED WITH AN ABERRATION IN A SIGNAL TRANSDUCTION PATHWAY SUCH AS CANCER OR A FIBROTIC DISORDER | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 2001-01-30 | — | — | US | disclosed |