Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | YES1 | P07947 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759348 | 0.90 | MAPK1 (0.53) | MAPTPIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL5757271 | 0.87 | MAPK1 (0.54) | TP53MAPTPIK3CAMAPK8MAPK9 | |
| SCHEMBL5757148 | 0.87 | LMNA (0.52) | TP53MAPTPIK3CAMAPK8MAPK9 | |
| SCHEMBL6767084 | 0.87 | PIK3CA (0.49) | TP53MAPTPIK3CAMAPK8MAPK9 | |
| SCHEMBL6765837 | 0.86 | ABCG2 (0.51) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL5761732 | 0.84 | ABCG2 (0.48) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL5759397 | 0.84 | NPC1 (0.57) | MAPTPIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL6771783 | 0.82 | RAB9A (0.54) | MAPTPIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL5758412 | 0.82 | MAPK1 (0.48) | MAPTPIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4697024 | 0.82 | MAPK1 (0.56) | PIK3CAMAPK8MAPK9MAPK10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727252-B1 | THE SERINE/THREONINE KINASE FAMILY INCLUDES MEMBERS THAT REGULATE CELL GROWTH, MIGRATION, DIFFERENTIATION, GENE EXPRESSION, MUSCLE CONTRACTION, GLUCOSE METABOLISM, CELLULAR PROTEIN SYNTHESIS, AND REGULATION OF THE CELL CYCLE | ZENTARIS AG (DE) | 2004-04-27 | — | — | US | disclosed |
| US-6180631-B1 | PREVENTING AND TREATING SERINE/THREONINE PROTEIN KINASE-RELATED ABNORMAL CONDITIONS IN MAMMALS ASSOCIATED WITH AN ABERRATION IN A SIGNAL TRANSDUCTION PATHWAY SUCH AS CANCER OR A FIBROTIC DISORDER | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 2001-01-30 | — | — | US | disclosed |