Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7493020 | 0.89 | CYP2D6 (0.57) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL7494310 | 0.87 | PDE5A (0.62) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL6450408 | 0.85 | PDE5A (0.60) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL7492370 | 0.83 | PDE5A (0.62) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL5560831 | 0.77 | PDE5A (0.66) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL3082745 | 0.76 | F2RL3 (0.61) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL5565271 | 0.76 | PDE5A (0.64) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL5560789 | 0.75 | PDE5A (0.57) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL5558869 | 0.75 | CYP2D6 (0.57) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL5565445 | 0.75 | PDE5A (0.63) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3108245-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING LOSS AND/OR DISTORTION OF TASTE OR SMELL | Henkin, Robert I. (US) | 2016-12-28 | — | — | EP | claimed |
| WO-2015126944-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING LOSS AND/OR DISTORTION OF TASTE OR SMELL | HENKIN ROBERT I (US) | 2015-08-27 | — | — | WO | claimed |
| CN-102438620-A | Compounds, compositions and use for anticancer therapy | MING YU | 2012-05-02 | — | — | CN | claimed |
| EP-3108245-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING LOSS AND/OR DISTORTION OF TASTE OR SMELL | Henkin, Robert I. (US) | 2016-12-28 | — | — | EP | disclosed |
| WO-2016011270-A2 | METHODS AND COMPOSITIONS FOR AMELIORATING SYMPTOMS ASSOCIATED WITH CHROMOSOMAL ABNORMALITIES | HENKIN ROBERT I (US) | 2016-01-21 | — | — | WO | disclosed |
| WO-2015126944-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING LOSS AND/OR DISTORTION OF TASTE OR SMELL | HENKIN ROBERT I (US) | 2015-08-27 | — | — | WO | disclosed |
| CN-102438620-A | Compounds, compositions and use for anticancer therapy | MING YU | 2012-05-02 | — | — | CN | disclosed |
| CN-1878464-A | Therapeutic delivery of carbon monoxide | HEMOCORM LTD (GB) | 2006-12-13 | — | — | CN | disclosed |
| CN-1679552-A | Preferential inhibition of proinflammatory cytokine release | YUNG SHIN PHARM IND CO LTD (CN) | 2005-10-12 | — | — | CN | disclosed |
| US-20040192680-A1 | Novel amides that activate soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-09-30 | — | — | US | disclosed |
| WO-2004060859-A2 | NOVEL AMIDES THAT ACTIVATE SOLUBLE GUANYLATE CYCLASE | ABBOTT LABORATORIES (US) | 2004-07-22 | — | — | WO | disclosed |
| US-20040121994-A1 | Novel amides that activate soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-06-24 | — | — | US | disclosed |
| US-6387942-B2 | PYRAZOLYL COMPOUND; ANTICOAGULANTS, ANTIPROLIFERATIVE AGENT | YUNG SHIN PHARMACEUTICAL IND. CO. LTD (TW) | 2002-05-14 | — | — | US | disclosed |
| US-20020004518-A1 | Method of treating disorders related to protease-activated receptors-induced cell activation | YUNG SHIN PHARMACEUTICAL IND. CO., LTD. (TW) | 2002-01-10 | — | — | US | disclosed |
| EP-1166785-A1 | Use of pyrazole derivatives for inhibiting thrombin-induced platelet aggregation | Yung Shin Pharmeutical Ind. Co., Ltd. (TW) | 2002-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121994-A1 | Novel amides that activate soluble guanylate cyclase | GUCY1A1, GUCY1B1, GUCY1A2 | PDE5A 8/4885CYP2D6 4143/4885CYP1A2 1926/4885 |
| US-20040192680-A1 | Novel amides that activate soluble guanylate cyclase | GUCY1A1, GUCY1B1, GUCY1A2 | PDE5A 8/4885CYP2D6 4143/4885CYP1A2 1926/4885 |
| US-20020004518-A1 | Method of treating disorders related to protease-activated receptors-induced cell activation | F2R, HPN, F2RL1 | PDE5A 3372/4885CYP2D6 2836/4885CYP1A2 1533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.