Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320164 | 0.77 | PARP1 (0.40) | TERTDRD2DRD4 | |
| SCHEMBL5842762 | 0.67 | TERT (0.52) | TERTHRH3DRD2 | |
| SCHEMBL6319381 | 0.67 | KDR (0.40) | — | |
| SCHEMBL2559154 | 0.64 | KDR (0.47) | LMNA | |
| SCHEMBL31159422 | 0.62 | HRH3 (0.59) | HRH3 | |
| SCHEMBL5414923 | 0.61 | SRC (0.44) | — | |
| SCHEMBL7265729 | 0.61 | CYP1A2 (0.55) | — | |
| SCHEMBL23828672 | 0.60 | HRH3 (0.81) | HRH3 | |
| SCHEMBL433324 | 0.60 | HRH3 (0.81) | HRH3 | |
| SCHEMBL13962337 | 0.60 | HRH3 (0.81) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |