Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 8/20 | 0.42 |
| ▸ | KDR | P35968 | 7/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 5/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | FLT1 | P17948 | 3/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | ABL2 | P42684 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6321236 | 0.81 | PDGFRB (0.51) | PDGFRBKDRFGFR1TLK2KIT | |
| SCHEMBL6328657 | 0.79 | PDGFRB (0.46) | PDGFRBKDRFGFR1TLK2KIT | |
| SCHEMBL6321318 | 0.78 | FLT1 (0.45) | PDGFRBKDRFGFR1TLK2KIT | |
| SCHEMBL6322218 | 0.77 | ALK (0.42) | PDGFRBKDRFGFR1KITFLT3 | |
| SCHEMBL6319360 | 0.77 | ALK (0.48) | PDGFRBKDRFGFR1TLK2KIT | |
| SCHEMBL6327898 | 0.77 | KDR (0.38) | PDGFRBKDRFGFR1TLK2KIT | |
| SCHEMBL6765924 | 0.76 | RET (0.62) | PDGFRBKDRFGFR1TLK2KIT | |
| SCHEMBL6324269 | 0.76 | RET (0.62) | PDGFRBKDRFGFR1TLK2KIT | |
| SCHEMBL6329305 | 0.75 | MET (0.43) | PDGFRBKDRFGFR1TLK2KIT | |
| SCHEMBL6323841 | 0.75 | PDGFRB (0.57) | PDGFRBKDRFGFR1TLK2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |