Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.61 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6764315 | 0.94 | KDM4E (0.58) | CYP1A2KDM4EKCNH2CYP2D6GUCY1B2 | |
| SCHEMBL6762222 | 0.84 | KDM4E (0.56) | CYP1A2KDM4EKCNH2CYP2D6GUCY1B2 | |
| SCHEMBL6760247 | 0.82 | SMN1; SMN2 (0.51) | KDM4EMEN1KMT2AALDH1A1GAA | |
| SCHEMBL6763555 | 0.80 | CNR1 (0.56) | CYP1A2KDM4EKCNH2CYP2D6GUCY1B2 | |
| SCHEMBL6764331 | 0.80 | KDM4E (0.46) | CYP1A2KDM4EKCNH2CYP2D6GUCY1B2 | |
| SCHEMBL6760280 | 0.79 | KDM4E (0.56) | CYP1A2KDM4EKCNH2CYP2D6GUCY1B2 | |
| SCHEMBL6762228 | 0.79 | ACKR3 (0.47) | CYP1A2KDM4EKCNH2CYP2D6GUCY1B2 | |
| SCHEMBL6763004 | 0.77 | MEN1 (0.47) | CYP1A2KDM4EKCNH2CYP2D6GUCY1B2 | |
| SCHEMBL6762478 | 0.77 | USP30 (0.44) | CYP1A2KDM4EKCNH2CYP2D6GUCY1B2 | |
| Benzydamine SCHEMBL29376229 | 0.77 | HRH3 (1.00) | CYP1A2KDM4EKCNH2CYP2D6GUCY1B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040048866-A1 | Indazole derivatives that are activators of soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-03-11 | — | — | US | claimed |
| WO-2003076408-A2 | INDAZOLE DERIVATIVES THAT ARE ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | ABBOTT LABORATORIES (US) | 2003-09-18 | — | — | WO | claimed |
| US-20040048866-A1 | Indazole derivatives that are activators of soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-03-11 | — | — | US | disclosed |
| WO-2003076408-A2 | INDAZOLE DERIVATIVES THAT ARE ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | ABBOTT LABORATORIES (US) | 2003-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048866-A1 | Indazole derivatives that are activators of soluble guanylate cyclase | GUCY1B1, GUCY1A1, GUCY1A2 | CYP1A2 199/4885KDM4E 2813/4885KCNH2 853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.