Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CFD | P00746 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6764933 | 0.93 | CNR2 (0.39) | AKR1C3CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL4603370 | 0.92 | AKR1C3 (0.41) | AKR1C3CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL6772466 | 0.91 | AKR1C3 (0.46) | AKR1C3CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL6771632 | 0.90 | AKR1C3 (0.41) | AKR1C3CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL6765566 | 0.90 | AKR1C3 (0.45) | AKR1C3CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL7012250 | 0.87 | ALDH1A1 (0.41) | AKR1C3CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL6771678 | 0.87 | AKR1C3 (0.40) | AKR1C3CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL6765104 | 0.87 | KDM4E (0.40) | AKR1C3CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL6767475 | 0.87 | AKR1C3 (0.42) | AKR1C3CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL7249486 | 0.86 | AKR1C3 (0.40) | AKR1C3CNR2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750214-B2 | PARTICULARLY IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | COLLIS ALAN JOHN (US) | 2004-06-15 | — | — | US | disclosed |
| US-6642242-B2 | Antiproliferative agents to treat benign prostatic hyperplasia | PFIZER INC. | 2003-11-04 | — | — | US | disclosed |
| US-6103738-A | Quinoline and quinazoline compounds useful in therapy | PFIZER INC. (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0877734-B1 | QUINOLINE AND QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER RES & DEV (IE) | 2000-07-12 | — | — | EP | disclosed |