Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 18/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.55 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6773096 | 0.89 | YTHDC1 (0.71) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL5460319 | 0.82 | YTHDC1 (0.63) | YTHDC1HSP90AA1HSP90AB1 | |
| SCHEMBL3392226 | 0.77 | HSP90AB1 (0.77) | YTHDC1HSP90AA1HSP90AB1 | |
| SCHEMBL3582728 | 0.77 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL6481387 | 0.77 | PDE4B (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3821565 | 0.76 | YTHDC1 (0.57) | YTHDC1HSP90AA1HSP90AB1 | |
| SCHEMBL6155940 | 0.76 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6675074 | 0.74 | PDE4B (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5458838 | 0.73 | YTHDC1 (0.76) | YTHDC1HSP90AA1HSP90AB1 | |
| SCHEMBL11827194 | 0.73 | HDAC6 (0.54) | YTHDC1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043324-B1 | PURINE DERIVATIVES AND MEDICINE CONTAINING THE SAME AS THE ACTIVE INGREDIENT | MITSUBISHI CHEM CORP (JP) | 2004-06-16 | — | — | EP | disclosed |
| US-6734187-B1 | ANTIASTHMATIC AGENTS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2004-05-11 | — | — | US | disclosed |
| EP-1043324-A1 | PURINE DERIVATIVES AND MEDICINE CONTAINING THE SAME AS THE ACTIVE INGREDIENT | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-10-11 | — | — | EP | disclosed |