Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.52 |
| ▸ | EBP | Q15125 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6032890 | 0.95 | ESR1 (0.56) | ESR1EBPKMT2AKDM4EMAPT | |
| SCHEMBL15570846 | 0.95 | ESR1 (0.56) | ESR1EBPKMT2AKDM4EMAPT | |
| SCHEMBL4300358 | 0.75 | KMT2A (0.61) | KMT2AMAPTKCNH2ADRA2APGR | |
| SCHEMBL15788560 | 0.75 | ESR1 (0.90) | ESR1EBPKMT2AKDM4EMAPT | |
| 4-Oh-Enclomiphene SCHEMBL14680624 | 0.75 | ESR1 (0.90) | ESR1EBPKMT2AKDM4EMAPT | |
| SCHEMBL7602301 | 0.75 | ESR1 (0.46) | ESR1EBPKMT2AKDM4EMAPT | |
| 4-Oh-Enclomiphene SCHEMBL6768536 | 0.75 | ESR1 (0.90) | ESR1EBPKMT2AKDM4EMAPT | |
| 4-Oh-Enclomiphene SCHEMBL17152123 | 0.75 | ESR1 (0.90) | ESR1EBPKMT2AKDM4EMAPT | |
| SCHEMBL7602287 | 0.75 | ESR1 (0.46) | ESR1EBPKMT2AKDM4EMAPT | |
| SCHEMBL27467107 | 0.75 | ESR1 (0.49) | ESR1EBPKMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743784-B2 | TRIARYLETHANES FOR TREATING SYMPTOMS, DISEASES AND CONDITIONS IN EXTRA-REPRODUCTIVE TRACT TISSUES, SUCH AS OSTEOPENIA, THAT ARE RESPONSIVE TO TREATMENT WITH ESTROGEN | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2004-06-01 | — | — | US | disclosed |
| US-20020045664-A1 | Estrogen mimetics lacking reproductive tract effects | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC | 2002-04-18 | — | — | US | disclosed |
| US-6323190-B1 | REPRODUCTIVE TRACT TISSUES AND CARDIOVASCULAR DISORDERS | THE UNIVERISTY OF GEORGIA RESEARCH FOUNDATION, INC. | 2001-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045664-A1 | Estrogen mimetics lacking reproductive tract effects | ESR2, ESRRA, GPER1 | ESR1 4/4885EBP 44/4885KMT2A 1621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.