Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.49 |
| ▸ | STS | P08842 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6768553 | 0.90 | PTPN2 (0.56) | PTPN2PTPN1PTPN6KMT2ANPC1 | |
| SCHEMBL22788738 | 0.83 | PTPN2 (0.58) | PTPN2PTPN1PTPN6KMT2ANPC1 | |
| SCHEMBL6773664 | 0.83 | F10 (0.57) | PTPN2PTPN1PTPN6KMT2ASTS | |
| SCHEMBL6108238 | 0.80 | PTPN2 (0.57) | PTPN2PTPN1PTPN6KMT2ANPC1 | |
| SCHEMBL27511463 | 0.80 | PTPN2 (0.77) | PTPN2PTPN1PTPN6KMT2ANPC1 | |
| SCHEMBL6107200 | 0.80 | KMT2A (0.57) | PTPN2PTPN1PTPN6KMT2ANPC1 | |
| SCHEMBL30304404 | 0.79 | DYRK1A (0.53) | KMT2ANPC1RAB9AGPR119MEN1 | |
| SCHEMBL21056670 | 0.79 | DYRK1A (0.53) | KMT2ANPC1RAB9AGPR119MEN1 | |
| SCHEMBL13188215 | 0.79 | PTPN2 (0.67) | PTPN2PTPN1PTPN6KMT2ANPC1 | |
| SCHEMBL27023071 | 0.78 | GPR119 (0.61) | PTPN2PTPN1PTPN6KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689780-B1 | PYRIDINE DERIVATIVES | ELI LILLY AND COMPANY | 2004-02-10 | — | — | US | disclosed |
| EP-1140905-B1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-1140905-A1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | ELI LILLY AND COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039117-A1 | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa | ELI LILLY AND COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |