Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 19/20 | 0.69 |
| ▸ | MMP13 | P45452 | 16/20 | 0.69 |
| ▸ | MMP2 | P08253 | 11/20 | 0.69 |
| ▸ | MMP3 | P08254 | 10/20 | 0.69 |
| ▸ | MMP9 | P14780 | 9/20 | 0.69 |
| ▸ | MMP7 | P09237 | 7/20 | 0.69 |
| ▸ | MMP14 | P50281 | 2/20 | 0.69 |
| ▸ | MMP8 | P22894 | 5/20 | 0.64 |
| ▸ | ADAM17 | P78536 | 12/20 | 0.59 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.58 |
| ▸ | ADAM9 | Q13443 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769244 | 1.00 | MMP1 (0.69) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL6769165 | 0.90 | MMP1 (0.55) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL6769162 | 0.90 | MMP1 (0.55) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL6771104 | 0.89 | MMP1 (0.79) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL6769525 | 0.88 | MMP1 (0.69) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL6769199 | 0.87 | MMP1 (0.68) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL14843152 | 0.87 | MMP1 (0.82) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL14850433 | 0.87 | MMP1 (0.82) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL6768856 | 0.86 | MMP1 (0.66) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL6768948 | 0.86 | MMP1 (0.66) | MMP1MMP13MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686355-B2 | TREATING HEART DISEASE, MULTIPLE SCLEROSIS, ARTHRITIS, ATHEROSCLEROSIS, AND OSTEOPOROSIS; ANTICANCER AGENTS | WARNER-LAMBERT COMPANY | 2004-02-03 | — | — | US | disclosed |
| EP-1233016-A1 | Biphenyl sulfonamides useful as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2002-08-21 | — | — | EP | disclosed |