SCHEMBL6769402

SCHEMBL6769402

CN(C)c1cc2c(=O)[nH]cnc2cn1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IP6K1 Q92551 3/20 0.58
PARP1 P09874 9/20 0.50
KDM4A O75164 1/20 0.47
KDM4B O94953 1/20 0.47
KDM5C P41229 1/20 0.47
KDM4C Q9H3R0 1/20 0.47
KDM5B Q9UGL1 1/20 0.47
KDM3A Q9Y4C1 1/20 0.47
CHEK1 O14757 2/20 0.46
PIM1 P11309 2/20 0.46
AKT1 P31749 1/20 0.46
FLT3 P36888 1/20 0.46
PIM3 Q86V86 1/20 0.46
RPS6KA3 P51812 1/20 0.46
MKNK1 Q9BUB5 1/20 0.45
SLC2A1 P11166 1/20 0.45
PDPK1 O15530 1/20 0.43
CA12 O43570 1/20 0.43
ALOX15 P16050 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7657502 0.77 PARP1 (0.59) IP6K1PARP1KDM4AKDM4BKDM5C
SCHEMBL669366 0.74 PARP1 (0.59) IP6K1PARP1KDM4AKDM4BKDM5C
SCHEMBL7970843 0.74 PARP1 (0.59) IP6K1PARP1KDM4AKDM4BKDM5C
SCHEMBL869256 0.74 PARP1 (0.59) IP6K1PARP1KDM4AKDM4BKDM5C
SCHEMBL8976535 0.73 IP6K1 (1.00) IP6K1PARP1CHEK1PIM1AKT1
SCHEMBL21331974 0.73 PARP1 (0.54) IP6K1PARP1KDM4AKDM4BKDM5C
SCHEMBL6769400 0.73 PDE9A (0.38) IP6K1PDPK1
SCHEMBL31020875 0.73 IP6K1 (1.00) IP6K1PARP1CHEK1PIM1AKT1
SCHEMBL18237710 0.73 PARP1 (0.50) IP6K1PARP1KDM4AKDM4BKDM5C
SCHEMBL22533946 0.70 IP6K1 (0.77) IP6K1PARP1KDM4AKDM4BKDM5C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6174889-B1 PROTEIN TYROSINE KINASE INHIBITORS RELATED TO BIOISOSTERES OF QUINOLINE AND QUINAZOLINE DERIVATIVES; ANTICARCINOGENIC AND -TUMOR AGENTS; PSORIASIS; RESTENOSIS; RHEUMATOID ARTHRITIS, AUTOIMMUNE DISEASE, ALLERGY, ASTHMA AND GRAFT REJECTION GLAXO WELLCOME INC. 2001-01-16 US claimed
US-6723726-B1 Protein tyrosine kinase inhibitors SMITHKLINE BEECHAM CORPORATION 2004-04-20 US disclosed
EP-0912570-B1 BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS GLAXO GROUP LTD (GB) 2003-09-10 EP disclosed
EP-1304110-A2 Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors GLAXO GROUP LIMITED (GB) 2003-04-23 EP disclosed
US-6174889-B1 PROTEIN TYROSINE KINASE INHIBITORS RELATED TO BIOISOSTERES OF QUINOLINE AND QUINAZOLINE DERIVATIVES; ANTICARCINOGENIC AND -TUMOR AGENTS; PSORIASIS; RESTENOSIS; RHEUMATOID ARTHRITIS, AUTOIMMUNE DISEASE, ALLERGY, ASTHMA AND GRAFT REJECTION GLAXO WELLCOME INC. 2001-01-16 US disclosed
US-6169091-B1 TREATMENT OF PSORIASIS, FIBROSIS, ATHEROSCLEROSIS, RESTENOSIS, AUTO-IMMUNE DISEASE, ALLERGY, ASTHMA GLAXO WELLCOME INC. 2001-01-02 US disclosed