Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | SYK | P43405 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766065 | 0.92 | SYK (0.51) | MKNK1ROCK2ROCK1SYKMAPK1 | |
| SCHEMBL6639550 | 0.88 | SYK (0.53) | MKNK1ROCK2ROCK1SYKMAPK1 | |
| SCHEMBL6771473 | 0.87 | SYK (0.66) | MKNK1ROCK2ROCK1SYKEGFR | |
| SCHEMBL6769085 | 0.86 | SYK (0.52) | MKNK1ROCK2ROCK1SYKMAPK1 | |
| SCHEMBL6611762 | 0.84 | SYK (0.49) | MKNK1ROCK2ROCK1SYKMAPK1 | |
| SCHEMBL6766687 | 0.84 | RPS6KB1 (0.53) | MKNK1ROCK2ROCK1SYKMAPK1 | |
| SCHEMBL6644053 | 0.83 | SYK (0.67) | SYKMAPK1HTTEGFR | |
| SCHEMBL6770452 | 0.82 | RPS6KB1 (0.51) | MKNK1ROCK2ROCK1SYKMAPK1 | |
| SCHEMBL6771304 | 0.81 | SYK (0.47) | MKNK1ROCK2ROCK1SYKMAPK1 | |
| SCHEMBL6769928 | 0.81 | RPS6KB1 (0.52) | ROCK2ROCK1SYKMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762189-B1 | HEPATITIS B VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS ANTIPROLIFERATION AGENTS; REDUCED CHANCE OF TOXICITY, SIDE EFFECTS, AND DEVELOPMENT OF RESISTANT VIRAL STRAINS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2004-07-13 | — | — | US | disclosed |