Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.41 |
| ▸ | EDNRB | P24530 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961539 | 0.87 | EDNRA (0.34) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL6772184 | 0.87 | EDNRA (0.38) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL9089818 | 0.86 | EDNRA (0.37) | EDNRAEDNRBTP53MAPTKDM4E | |
| SCHEMBL8348292 | 0.85 | EDNRA (0.48) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL6640800 | 0.85 | EDNRB (0.41) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL6772650 | 0.83 | TDP1 (0.34) | TP53MAPTMEN1KMT2A | |
| SCHEMBL6770266 | 0.83 | EDNRB (0.39) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL6778008 | 0.83 | EDNRB (0.40) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL8351866 | 0.83 | EDNRA (0.50) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL8346135 | 0.82 | EDNRA (0.50) | EDNRAEDNRBTP53MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| CN-1066441-C | Phenyl sulfonamide endothelin antagonists | SQUIBB & SONS INC (US) | 2001-05-30 | — | — | CN | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |