Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.46 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 5/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | WEE1 | P30291 | 4/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.42 |
| ▸ | PAK4 | O96013 | 3/20 | 0.42 |
| ▸ | FYN | P06241 | 3/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766160 | 0.93 | PDGFRB (0.52) | LCKPTK6PDE4BSYKPDGFRA | |
| SCHEMBL6770721 | 0.91 | PDGFRB (0.53) | LCKSYKMKNK1PDGFRAPDGFRB | |
| SCHEMBL6765966 | 0.84 | PDGFRB (0.62) | LCKSYKPDGFRAPDGFRBEGFR | |
| SCHEMBL6639550 | 0.80 | SYK (0.53) | LCKSYKMKNK1EGFRDAPK3 | |
| SCHEMBL6770452 | 0.80 | RPS6KB1 (0.51) | SYKMKNK1EGFRJAK2JAK3 | |
| SCHEMBL6772093 | 0.80 | PDGFRA (0.57) | LCKPDE4BSYKPDGFRAPDGFRB | |
| Indazole SCHEMBL27469572 | 0.80 | PDE4B (0.40) | PDE4BABL1 | |
| SCHEMBL6771473 | 0.79 | SYK (0.66) | SYKMKNK1EGFRJAK3ROCK1 | |
| SCHEMBL6769723 | 0.79 | EGFR (0.50) | LCKSYKMKNK1PDGFRAPDGFRB | |
| SCHEMBL6769085 | 0.79 | SYK (0.52) | SYKMKNK1EGFRJAK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1181057-C | Novel 5-pyrimidine carboxamide derivatives and the pharmaceutical compositions containing said derivatives | ����ҩƷ��ҵ��ʽ���� | 2004-12-22 | — | — | CN | disclosed |
| US-6762189-B1 | HEPATITIS B VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS ANTIPROLIFERATION AGENTS; REDUCED CHANCE OF TOXICITY, SIDE EFFECTS, AND DEVELOPMENT OF RESISTANT VIRAL STRAINS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2004-07-13 | — | — | US | disclosed |
| CN-1390203-A | Novel 5-pyrimidine carboxamide derivatives and the pharmaceutical compositions containing said derivatives | DONG WHA PHARM IND CO LTD (KR) | 2003-01-08 | — | — | CN | disclosed |