Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769391 | 0.94 | PDGFRB (0.66) | PDGFRAPDGFRBKDM5BEGFRSYK | |
| SCHEMBL6769054 | 0.86 | ROCK1 (0.54) | PDGFRAPDGFRBLRRK2EGFRSYK | |
| SCHEMBL6770452 | 0.84 | RPS6KB1 (0.51) | EGFRSYKROCK2ROCK1IRAK4 | |
| SCHEMBL6769928 | 0.83 | RPS6KB1 (0.52) | EGFRSYKROCK2ROCK1KDR | |
| SCHEMBL6611762 | 0.83 | SYK (0.49) | EGFRSYKROCK2ROCK1WEE1 | |
| SCHEMBL6766687 | 0.82 | RPS6KB1 (0.53) | EGFRSYKROCK2ROCK1CDK9 | |
| SCHEMBL7077905 | 0.80 | PDGFRB (0.67) | PDGFRAPDGFRBKDM5BLRRK2SMYD2 | |
| SCHEMBL6770704 | 0.80 | LCK (0.46) | PDGFRAPDGFRBLRRK2EGFRSYK | |
| SCHEMBL6769445 | 0.80 | HSD17B10 (0.46) | EGFR | |
| SCHEMBL6769723 | 0.80 | EGFR (0.50) | PDGFRAPDGFRBLRRK2EGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762189-B1 | HEPATITIS B VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS ANTIPROLIFERATION AGENTS; REDUCED CHANCE OF TOXICITY, SIDE EFFECTS, AND DEVELOPMENT OF RESISTANT VIRAL STRAINS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2004-07-13 | — | — | US | disclosed |