Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11079515 | 0.83 | TNF (0.55) | ALDH1A1LMNAHTTSMN1; SMN2TNF | |
| SCHEMBL759261 | 0.81 | SLC6A4 (0.49) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A4 | |
| SCHEMBL6770175 | 0.81 | SLC6A2 (0.48) | ALDH1A1LMNAHTTSMN1; SMN2TNF | |
| SCHEMBL22504108 | 0.81 | TNF (0.45) | ALDH1A1LMNAHTTSMN1; SMN2TNF | |
| SCHEMBL4468913 | 0.80 | TNF (0.44) | ALDH1A1LMNAHTTSMN1; SMN2TNF | |
| SCHEMBL13074863 | 0.79 | SLC6A4 (0.50) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A4 | |
| SCHEMBL6770906 | 0.79 | SLC6A4 (0.53) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL9883161 | 0.77 | SLC6A4 (0.48) | ALDH1A1LMNAHTTSMN1; SMN2SLC6A4 | |
| SCHEMBL15436939 | 0.76 | FNTA (0.39) | ALDH1A1LMNAHTTSMN1; SMN2TNF | |
| SCHEMBL4471203 | 0.75 | TNF (0.48) | ALDH1A1LMNAHTTSMN1; SMN2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821973-B2 | ANTAGONIZE THE PHARMACOLOGICAL ACTIONS OF THE ENDOGENOUS NEUROPEPTIDE TACHYKININS KNOWN AS NEUROKININS | ASTRAZENECA AB (SE) | 2004-11-23 | — | — | US | claimed |