Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770086 | 0.84 | TNF (0.40) | SLC6A2SLC6A4SLC6A3TNFALDH1A1 | |
| SCHEMBL11079515 | 0.83 | TNF (0.55) | SLC6A2SLC6A4SLC6A3TNFALDH1A1 | |
| SCHEMBL6769732 | 0.83 | TACR2 (0.55) | TACR2 | |
| SCHEMBL6769281 | 0.83 | ATM (0.50) | TNFTACR2 | |
| SCHEMBL4191873 | 0.81 | SLC6A4 (0.54) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL22504108 | 0.81 | TNF (0.45) | SLC6A2SLC6A4SLC6A3TNFALDH1A1 | |
| SCHEMBL6770904 | 0.81 | ALDH1A1 (0.46) | SLC6A2SLC6A4SLC6A3TNFCYP3A4 | |
| SCHEMBL4468913 | 0.80 | TNF (0.44) | SLC6A2SLC6A4SLC6A3TNFCYP3A4 | |
| SCHEMBL6249332 | 0.78 | HTR2A (0.53) | SLC6A2SLC6A4CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL6770177 | 0.75 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821973-B2 | ANTAGONIZE THE PHARMACOLOGICAL ACTIONS OF THE ENDOGENOUS NEUROPEPTIDE TACHYKININS KNOWN AS NEUROKININS | ASTRAZENECA AB (SE) | 2004-11-23 | — | — | US | claimed |