Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775212 | 0.83 | MAPK1 (0.40) | POLBHPGDMAPK1MAPTALDH1A1 | |
| SCHEMBL6775215 | 0.83 | MAPK1 (0.40) | POLBHPGDMAPK1MAPTALDH1A1 | |
| SCHEMBL6770838 | 0.83 | PPARG (0.41) | POLBHPGDMAPK1MAPTALDH1A1 | |
| SCHEMBL7220490 | 0.82 | KDM4E (0.40) | POLBHPGDMAPTALDH1A1PPARG | |
| SCHEMBL7220487 | 0.82 | KDM4E (0.40) | POLBHPGDMAPTALDH1A1PPARG | |
| SCHEMBL6770258 | 0.82 | POLB (0.44) | POLBHPGDMAPK1MAPTALDH1A1 | |
| SCHEMBL6770263 | 0.82 | POLB (0.44) | POLBHPGDMAPK1MAPTALDH1A1 | |
| SCHEMBL6770835 | 0.76 | KMT2A (0.42) | POLBHPGDMAPK1MAPTALDH1A1 | |
| SCHEMBL6776366 | 0.76 | KMT2A (0.42) | POLBHPGDMAPK1MAPTALDH1A1 | |
| SCHEMBL6776432 | 0.76 | PPARG (0.39) | POLBHPGDMAPK1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821994-B2 | A PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR REGULATOR, AN OXAZOL-4-YL-METHYLFURAN-2-YL-2-PROPENYLTHIO- OR SULFONYL- OR SULFINYL-ACETIC ACID OR METHYL ESTER | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-11-23 | — | — | US | claimed |