Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 5/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220487 | 1.00 | KDM4E (0.40) | KDM4ESMN1; SMN2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL6770927 | 0.82 | POLB (0.45) | KDM4ESMN1; SMN2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL6776054 | 0.80 | KDM4E (0.39) | KDM4ESMN1; SMN2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL6776046 | 0.80 | KDM4E (0.39) | KDM4ESMN1; SMN2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL6780496 | 0.73 | KDM4E (0.36) | KDM4EHPGDRAB9ANPC1LMNA | |
| SCHEMBL6780504 | 0.73 | KDM4E (0.36) | KDM4EHPGDRAB9ANPC1LMNA | |
| SCHEMBL6771330 | 0.73 | HSD17B10 (0.41) | KDM4ESMN1; SMN2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL6771328 | 0.73 | HSD17B10 (0.41) | KDM4ESMN1; SMN2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL6776575 | 0.71 | PPARA (0.37) | KDM4ESMN1; SMN2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL6776581 | 0.71 | PPARA (0.37) | KDM4ESMN1; SMN2HPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589969-B1 | A peroxisome proliferator activated receptor regulator containing a compound of formula (I) Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive | ONO PHARMACEUTICAL CO., LTD. (JP) | 2003-07-08 | — | — | US | claimed |