Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1769204 | 0.84 | KMT2A (0.59) | KMT2ACYP1A2CYP2D6ALDH1A1MAPT | |
| SCHEMBL27504484 | 0.82 | KMT2A (0.66) | KMT2ACYP1A2CYP2D6ALDH1A1MAPT | |
| SCHEMBL27474677 | 0.82 | KMT2A (0.71) | KMT2ACYP1A2CYP2D6ALDH1A1MAPT | |
| SCHEMBL11602621 | 0.80 | KMT2A (0.64) | KMT2ACYP1A2CYP2D6ALDH1A1MAPT | |
| SCHEMBL8483965 | 0.80 | MAPT (0.65) | KMT2ACYP1A2CYP2D6MAPTMGLL | |
| SCHEMBL7819807 | 0.78 | SMN1; SMN2 (0.60) | KMT2ACYP1A2CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL28621572 | 0.78 | KMT2A (0.51) | KMT2ACYP1A2CYP2D6ALDH1A1MAPT | |
| SCHEMBL27750481 | 0.78 | KMT2A (0.51) | KMT2ACYP1A2CYP2D6ALDH1A1MAPT | |
| SCHEMBL7392742 | 0.77 | KMT2A (0.72) | KMT2ACYP1A2CYP2D6ALDH1A1LMNA | |
| SCHEMBL9176904 | 0.77 | MAPT (0.55) | KMT2AALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1326850-C | Tricyclic farnesyl protein transferase inhibitors | SCHERING CORP (US) | 2007-07-18 | — | — | CN | disclosed |
| US-6740661-B2 | TRICYCLIC IMINE CONTAINING COMPOUNDS HAVING IMIDAZOLE SUBSTITUENT; ANTITUMOR AGENTS | SCHERING CORPORATION | 2004-05-25 | — | — | US | disclosed |
| US-6372747-B1 | ENZYME INHIBITORS AND ANTICARCINOGENIC AGENTS | SCHERING CORPORATION | 2002-04-16 | — | — | US | disclosed |
| CN-1334811-A | Tricyclic farnesyl protein transferase inhibitors | SCHERING CORP (US) | 2002-02-06 | — | — | CN | disclosed |