SCHEMBL6772008

SCHEMBL6772008

C1=CNC=C2CNCC2=C1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20039935 0.62
SCHEMBL21100360 0.58
SCHEMBL669431 0.54
SCHEMBL19936261 0.53
SCHEMBL31287303 0.52
SCHEMBL4552477 0.51
SCHEMBL5158080 0.47
Piperazine SCHEMBL5904126 0.47 HIF1A (0.43)
SCHEMBL24916721 0.46
SCHEMBL11768224 0.44 PNMT (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6713634-B2 SEROTONIN RECEPTOR ANTAGONIST DAIICHI SUNTORY PHARMA CO., LTD. (JP) 2004-03-30 US disclosed
US-20030166926-A1 Pyrroloazepine derivatives SUNTORY LIMITED (JP) 2003-09-04 US disclosed
EP-0915881-B1 PYRROLOAZEPINE COMPOUNDS SUNTORY LTD (JP) 2003-01-08 EP disclosed
US-6489473-B2 FOR THERAPY AND PROPHYLAXIS OF ISCHEMIC HEART DISEASES SUCH AS ANGINA PECTORIS, ARRHYTHMIA, MYOCARDIAL INFARCTION, CONGESTIVE HEART FAILURE, CEREBRAL INFARCTION AND CEREBRAL SEQUELAE AFTER SUBARACHNOID HEMORRHAGE, HYPERTENSION SUNTORY LIMITED (JP) 2002-12-03 US disclosed
US-20020072515-A1 Pyrroloazepine derivatives SUNTORY LIMITED (JP) 2002-06-13 US disclosed
EP-0807632-B1 PYRROLOAZEPINE DERIVATIVES SUNTORY LTD (JP) 2002-04-17 EP disclosed
US-6258805-B1 TREATMENT OF BRAIN DISORDERS AND HYPERTENSION SUNTORY LIMITED (JP) 2001-07-10 US disclosed
US-6211362-B1 CHEMICAL INTERMEDIATE FOR DRUGS SUNTORY LIMITED (JP) 2001-04-03 US disclosed
US-6187772-B1 Pyrroloazepine compounds SUNTORY LIMITED (JP) 2001-02-13 US disclosed
EP-0915881-A1 PYRROLOAZEPINE COMPOUNDS SUNTORY LIMITED (JP) 1999-05-19 EP disclosed
WO-1998041527-A1 PYRROLOAZEPINE COMPOUNDS SUNTORY LIMITED (JP) 1998-09-24 WO disclosed
EP-0807632-A1 PYRROLOAZEPINE DERIVATIVES SUNTORY LIMITED (JP) 1997-11-19 EP disclosed