Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772403 | 1.00 | MAPT (0.60) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL5059126 | 0.92 | MAPT (0.70) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL5059128 | 0.92 | MAPT (0.70) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL25806424 | 0.87 | MAPT (0.64) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL27565894 | 0.86 | MAPT (0.67) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL7392884 | 0.84 | MAPT (0.60) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL11780640 | 0.84 | L3MBTL1 (0.56) | MAPTRAB9AGAALMNAL3MBTL1 | |
| SCHEMBL12869645 | 0.84 | MAPT (0.64) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL11780648 | 0.84 | L3MBTL1 (0.56) | MAPTRAB9AGAALMNAL3MBTL1 | |
| SCHEMBL25806416 | 0.83 | MAPT (0.58) | MAPTRAB9ACA1CA2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828344-B1 | Direct inhibition of the activity of phospholipase A2 has been suggested as a useful mechanism for a therapeutic agent for inflammation | GENETICS INSTITUTE, LLC | 2004-12-07 | — | — | US | disclosed |