Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 14/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771681 | 0.95 | EDNRA (0.40) | EDNRAAGTR1EDNRB | |
| SCHEMBL9089410 | 0.89 | EDNRB (0.44) | EDNRAEDNRB | |
| SCHEMBL4770889 | 0.89 | EDNRB (0.40) | EDNRAEDNRB | |
| SCHEMBL6640800 | 0.88 | EDNRB (0.41) | EDNRAEDNRB | |
| SCHEMBL7956558 | 0.88 | MAPT (0.41) | EDNRAEDNRB | |
| SCHEMBL6771197 | 0.87 | EDNRB (0.54) | EDNRAEDNRB | |
| SCHEMBL6770266 | 0.87 | EDNRB (0.39) | EDNRAEDNRB | |
| SCHEMBL6778008 | 0.87 | EDNRB (0.40) | EDNRAEDNRB | |
| SCHEMBL9089380 | 0.86 | EDNRB (0.45) | EDNRAEDNRB | |
| SCHEMBL8044496 | 0.86 | EDNRB (0.39) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | disclosed |