Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | EDNRB | P24530 | 6/20 | 0.40 |
| ▸ | EDNRA | P25101 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770889 | 0.90 | EDNRB (0.40) | MAPTEDNRBEDNRATP53 | |
| SCHEMBL6640800 | 0.90 | EDNRB (0.41) | MAPTEDNRBEDNRATP53 | |
| SCHEMBL6771681 | 0.89 | EDNRA (0.40) | MAPTEDNRBEDNRATP53 | |
| SCHEMBL6772130 | 0.89 | TP53 (0.39) | MAPTEDNRBEDNRATP53 | |
| SCHEMBL6771197 | 0.89 | EDNRB (0.54) | EDNRBEDNRA | |
| SCHEMBL6778008 | 0.88 | EDNRB (0.40) | MAPTEDNRBEDNRATP53 | |
| SCHEMBL6770266 | 0.88 | EDNRB (0.39) | MAPTEDNRBEDNRATP53 | |
| SCHEMBL8044496 | 0.88 | EDNRB (0.39) | MAPTEDNRBEDNRATP53 | |
| SCHEMBL6772637 | 0.88 | EDNRA (0.41) | EDNRBEDNRA | |
| SCHEMBL7947866 | 0.88 | EDNRB (0.39) | MAPTEDNRBEDNRATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271248-B1 | USED IN TREATING HYPERTENSION, PULMONARY HYPERTENSION, RENAL/ GLOMERULAR/MESANGIAL CELL DISORDERS, ENDOTOXEMIA, ISCHEMIA, TUMOR GROWTH, ATHERSCLEROSIS, RESTENOSIS, SUBARACHNOID HEMORRHAGE, PROSTATIC HYPERTROPHY, CONGESTIVE HEART FAILURE | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6080774-A | Substituted biphenylsulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-27 | — | — | US | disclosed |
| EP-0768305-A1 | N-Isoxazolyl-biphenylsulfonamide derivatives, their preparation and their use as endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-16 | — | — | EP | disclosed |