Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777479 | 0.91 | EDNRB (0.44) | EDNRAEDNRB | |
| SCHEMBL7956927 | 0.84 | EDNRA (0.43) | EDNRAEDNRB | |
| SCHEMBL6640800 | 0.83 | EDNRB (0.41) | EDNRAEDNRB | |
| SCHEMBL6772653 | 0.83 | NPSR1 (0.35) | EDNRAEDNRB | |
| SCHEMBL4767425 | 0.83 | EDNRB (0.44) | EDNRAEDNRB | |
| SCHEMBL6777059 | 0.80 | EDNRA (0.46) | EDNRA | |
| SCHEMBL6776271 | 0.80 | EDNRA (0.46) | EDNRA | |
| SCHEMBL6772980 | 0.80 | EDNRB (0.41) | EDNRAEDNRB | |
| SCHEMBL6771346 | 0.79 | EDNRB (0.43) | EDNRAEDNRB | |
| SCHEMBL9087795 | 0.79 | EDNRA (0.40) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | disclosed |