Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772650 | 0.85 | TDP1 (0.34) | NPSR1TDP1TP53MAPTALDH1A1 | |
| SCHEMBL6772985 | 0.83 | EDNRA (0.42) | EDNRBEDNRA | |
| SCHEMBL6772649 | 0.81 | TDP1 (0.34) | TDP1ALDH1A1 | |
| SCHEMBL7956927 | 0.81 | EDNRA (0.43) | NPSR1TDP1TP53MAPTEDNRB | |
| SCHEMBL6777479 | 0.80 | EDNRB (0.44) | EDNRBEDNRA | |
| SCHEMBL6777059 | 0.79 | EDNRA (0.46) | EDNRA | |
| SCHEMBL7086349 | 0.75 | TSHR (0.40) | NPSR1TP53EDNRAALDH1A1 | |
| SCHEMBL4767425 | 0.73 | EDNRB (0.44) | EDNRBEDNRA | |
| SCHEMBL4632118 | 0.72 | EDNRB (0.42) | TP53MAPTEDNRBEDNRAALDH1A1 | |
| SCHEMBL4632438 | 0.71 | MMP2 (0.37) | TP53MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | disclosed |