Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.55 |
| ▸ | PDE6C | P51160 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001460 | 0.87 | PDE5A (0.47) | PDE5APDE6CKMT2AMEN1ALDH1A1 | |
| SCHEMBL6777238 | 0.86 | PDE5A (0.42) | PDE5AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL6776962 | 0.83 | PDE5A (0.54) | PDE5APDE6C | |
| SCHEMBL7002254 | 0.82 | PDE5A (0.46) | PDE5APDE6CKMT2AMEN1ALDH1A1 | |
| SCHEMBL6446885 | 0.81 | PDE5A (0.70) | PDE5APDE6CKMT2AMEN1ALDH1A1 | |
| SCHEMBL7001512 | 0.81 | PDE5A (0.42) | PDE5AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL7004010 | 0.81 | PDE5A (0.40) | PDE5AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL13500487 | 0.81 | PDE5A (0.67) | PDE5A | |
| SCHEMBL6443202 | 0.80 | PDE5A (0.75) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL6778726 | 0.79 | PDE5A (0.52) | PDE5APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |
| EP-1222190-A1 | 5-(2-SUBSTITUTED-5-HETEROCYCLYLSULPHONYLPYRID-3-YL)-DIHYDROPYRAZOLO[4,3-D]PYRIMIDIN-7-ONES AS PHOSPHODIESTERASE INHIBITORS | Pfizer Limited (GB) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001027112-A1 | 5-(2-SUBSTITUTED-5-HETEROCYCLYLSULPHONYLPYRID-3-YL)-DIHYDROPYRAZOLO[4,3-D]PYRIMIDIN-7-ONES AS PHOSPHODIESTERASE INHIBITORS | PFIZER LIMITED (GB) | 2001-04-19 | — | — | WO | disclosed |