Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | PDE6C | P51160 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6773014 | 0.83 | PDE5A (0.55) | PDE5APDE6C | |
| SCHEMBL6773195 | 0.80 | PDE5A (0.48) | PDE5APDE6C | |
| SCHEMBL6443202 | 0.79 | PDE5A (0.75) | PDE5APDE3BPDE3APDE6C | |
| SCHEMBL6782391 | 0.79 | PDE5A (0.61) | PDE5APDE3BPDE3APDE6CKDM4E | |
| SCHEMBL6441791 | 0.76 | PDE5A (0.67) | PDE5A | |
| SCHEMBL6778726 | 0.75 | PDE5A (0.52) | PDE5APDE6C | |
| SCHEMBL6777025 | 0.73 | PDE5A (0.51) | PDE5APDE6C | |
| SCHEMBL6777354 | 0.73 | PDE5A (0.58) | PDE5APDE6C | |
| SCHEMBL6772442 | 0.73 | PDE5A (0.50) | PDE5APDE6C | |
| SCHEMBL6777134 | 0.73 | PDE5A (0.50) | PDE5APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |