Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.52 |
| ▸ | TUBB | P07437 | 2/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.52 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.52 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.52 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6767153 | 0.99 | ESR1 (0.53) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL6765919 | 0.89 | ESR1 (0.56) | ESR1ESR2CNR1TDP1 | |
| Hydrochloric Acid SCHEMBL6767212 | 0.89 | ESR1 (0.55) | ESR1ESR2CNR1TDP1 | |
| SCHEMBL6836596 | 0.85 | ESR1 (0.49) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| 1,2-Dichloroethane SCHEMBL6766357 | 0.85 | ESR1 (0.53) | ESR1ESR2CNR1TDP1 | |
| Chlorobenzene SCHEMBL6765632 | 0.83 | ESR1 (0.49) | ESR1ESR2CNR1TDP1 | |
| SCHEMBL11546641 | 0.80 | TUBB4A (0.69) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL6773068 | 0.80 | ESR1 (0.66) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| Hydrochloric Acid SCHEMBL6767144 | 0.80 | ESR1 (0.67) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL5026252 | 0.79 | CNR1 (0.78) | ESR1ESR2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713494-B1 | SUCH AS 6-HYDROXY-2-(4-HYDROXYPHENYL)-3-(4-(2-PIPERIDINYL-ETHOXY)BENZOYL)BENZOTHIOPHENE HYDROCHLORIDE SALT; OSTEO-POROSIS | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| EP-0826682-B1 | Amorphous Bentothiophene, method of preparation and method of use. | LILLY CO ELI (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-0826682-A1 | Amorphous benzothiophenes, methods of preparation, and methods of use | ELI LILLY AND COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |