Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | MC4R | P32245 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4922997 | 0.90 | LMNA (0.55) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL28463472 | 0.90 | LMNA (0.55) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL27626473 | 0.90 | LMNA (0.55) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL1713427 | 0.90 | LMNA (0.55) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL7459001 | 0.90 | LMNA (0.55) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL7291562 | 0.90 | LMNA (0.55) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL5453145 | 0.90 | LMNA (0.55) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL879237 | 0.90 | LMNA (0.55) | CYP2D6MC4ROPRM1OPRK1OPRL1 | |
| SCHEMBL3142112 | 0.84 | HRH3 (0.43) | CYP2D6MC4ROPRK1LMNAHTT | |
| SCHEMBL9683895 | 0.83 | CYP2D6 (0.55) | CYP2D6MC4ROPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756370-B1 | POTENT 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2004-06-29 | — | — | US | disclosed |