Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40860 | 0.81 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL5773810 | 0.81 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL5773320 | 0.78 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL5771909 | 0.77 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL6778439 | 0.77 | MAPK14 (0.79) | MAPK14 | |
| SCHEMBL5771778 | 0.76 | MAPK14 (0.71) | MAPK14 | |
| SCHEMBL5771772 | 0.75 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL15008027 | 0.75 | MAPK14 (0.58) | MAPK14 | |
| SCHEMBL6778310 | 0.74 | MAPK14 (0.74) | MAPK14 | |
| SCHEMBL21631838 | 0.73 | MAPK14 (0.83) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696464-B2 | POTENT INHIBITORS OF MAP KINASES, PREFERABLY P38 KINASE; USEFUL IN TREATMENT OF INFLAMMATION, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, CANCER, REPERFUSION OR ISCHEMIA IN STROKE OR HEART ATTACK | PFIZER INC | 2004-02-24 | — | — | US | disclosed |