Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tebanicline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 3/20 | 1.00 |
| ▸ | CHRNA4 known ✓ | P43681 | 3/20 | 1.00 |
| ▸ | CHRNA3 | P32297 | 4/20 | 1.00 |
| ▸ | CHRNB4 | P30926 | 2/20 | 1.00 |
| ▸ | CHRNA7 | P36544 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tebanicline SCHEMBL120178 | 1.00 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL29711092 | 1.00 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL120179 | 1.00 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL15663029 | 0.98 | CHRNA3 (0.97) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL15663031 | 0.98 | CHRNA3 (0.97) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| Tebanicline SCHEMBL7407195 | 0.98 | CHRNA3 (0.97) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL905233 | 0.89 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL8440116 | 0.89 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| Hydrochloric Acid SCHEMBL8437569 | 0.88 | CHRNA3 (0.97) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| Hydrochloric Acid SCHEMBL8435785 | 0.88 | CHRNA3 (0.97) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434573-A2 | IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF PAIN AND INFLAMMATION | Omeros Corporation (US) | 2004-07-07 | — | — | EP | claimed |
| US-20020028798-A1 | Irrigation solution and method for inhibition of pain and inflammation | OMEROS MEDICAL SYSTEMS | 2002-03-07 | — | — | US | claimed |
| WO-2000023062-A2 | IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF PAIN AND INFLAMMATION | OMEROS MEDICAL SYSTEMS, INC. (US) | 2000-04-27 | — | — | WO | claimed |
| US-6054451-A | THE EFFECTIVENESS OF (R) OR (S) 5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE, IS SIGNIFICANTLY POTENTIATED BY ADMINISTERING AN ANALGESIC-POTENTIATING AMOUNT FOR SAID ANALGESIC OF AT LEAST ONE NONTOXIC NMDA RECEPTOR | ALGOS PHARMACEUTICAL CORPORATION (US) | 2000-04-25 | — | — | US | claimed |
| WO-1999053922-A1 | ANALGESIC COMPOSITIONS COMPRISING NMDA-ANTAGONISTS AND ABT-594 | ALGOS PHARMACEUTICAL CORPORATION (US) | 1999-10-28 | — | — | WO | claimed |
| US-5948793-A | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release | ABBOTT LABORATORIES (US) | 1999-09-07 | — | — | US | claimed |
| US-20220062252-A1 | CYCLOOXYGENASE INHIBITOR AND CALCIUM CHANNEL ANTAGONIST COMPOSITIONS AND METHODS FOR USE IN UROLOGICAL PROCEDURES | OMEROS CORP (US) | 2022-03-03 | — | — | US | disclosed |
| US-20210290605-A1 | CYCLOOXYGENASE INHIBITOR AND CALCIUM CHANNEL ANTAGONIST COMPOSITIONS AND METHODS FOR USE IN UROLOGICAL PROCEDURES | OMEROS CORP (US) | 2021-09-23 | — | — | US | disclosed |
| US-20190083477-A1 | Cyclooxygenase Inhibitor and Calcium Channel Antagonist Compositions and Methods for Use in Urological Procedures | OMEROS CORP (US) | 2019-03-21 | — | — | US | disclosed |
| US-9855256-B2 | Cyclooxygenase inhibitor and calcium channel antagonist compositions and methods for use in urological procedures | OMEROS CORPORATION (US) | 2018-01-02 | — | — | US | disclosed |
| US-20170246150-A1 | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation | OMEROS CORPORATION | 2017-08-31 | — | — | US | disclosed |
| US-20170182007-A1 | Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation | OMEROS CORPORATION | 2017-06-29 | — | — | US | disclosed |
| EP-1881821-B1 | COMPOSITIONS COMPRISING KETOPROFEN AND CALCIUM CHANNEL ANTAGONIST FOR USE IN UROLOGICAL PROCEDURES | OMEROS CORP (US) | 2016-11-09 | — | — | EP | disclosed |
| WO-2000023062-A2 | IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF PAIN AND INFLAMMATION | OMEROS MEDICAL SYSTEMS, INC. (US) | 2000-04-27 | — | — | WO | disclosed |
| US-6054451-A | THE EFFECTIVENESS OF (R) OR (S) 5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE, IS SIGNIFICANTLY POTENTIATED BY ADMINISTERING AN ANALGESIC-POTENTIATING AMOUNT FOR SAID ANALGESIC OF AT LEAST ONE NONTOXIC NMDA RECEPTOR | ALGOS PHARMACEUTICAL CORPORATION (US) | 2000-04-25 | — | — | US | disclosed |
| US-6054451-A | THE EFFECTIVENESS OF (R) OR (S) 5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE, IS SIGNIFICANTLY POTENTIATED BY ADMINISTERING AN ANALGESIC-POTENTIATING AMOUNT FOR SAID ANALGESIC OF AT LEAST ONE NONTOXIC NMDA RECEPTOR | ALGOS PHARMACEUTICAL CORPORATION (US) | 2000-04-25 | — | — | US | disclosed |
| WO-1999064038-A1 | NOVEL ANALGESIC AGENTS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
| WO-1999053922-A1 | ANALGESIC COMPOSITIONS COMPRISING NMDA-ANTAGONISTS AND ABT-594 | ALGOS PHARMACEUTICAL CORPORATION (US) | 1999-10-28 | — | — | WO | disclosed |
| WO-1999053922-A1 | ANALGESIC COMPOSITIONS COMPRISING NMDA-ANTAGONISTS AND ABT-594 | ALGOS PHARMACEUTICAL CORPORATION (US) | 1999-10-28 | — | — | WO | disclosed |
| US-5948793-A | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release | ABBOTT LABORATORIES (US) | 1999-09-07 | — | — | US | disclosed |