Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6774506 | 1.00 | TDP1 (0.53) | TDP1CRHR1 | |
| SCHEMBL6773800 | 0.91 | CRHR1 (0.54) | TDP1CRHR1 | |
| SCHEMBL6773802 | 0.91 | CRHR1 (0.54) | TDP1CRHR1 | |
| SCHEMBL6775651 | 0.84 | CRHR1 (0.57) | TDP1CRHR1 | |
| SCHEMBL6775657 | 0.84 | CRHR1 (0.57) | TDP1CRHR1 | |
| SCHEMBL6774814 | 0.82 | CRHR1 (0.55) | TDP1CRHR1 | |
| SCHEMBL6778812 | 0.80 | CRHR1 (0.53) | TDP1CRHR1 | |
| SCHEMBL6778804 | 0.80 | CRHR1 (0.53) | TDP1CRHR1 | |
| SCHEMBL7220617 | 0.80 | CRHR1 (0.53) | TDP1CRHR1 | |
| SCHEMBL7219698 | 0.78 | CRHR1 (0.53) | TDP1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765008-B1 | PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES; ANXIOLYTIC AGENTS; NERVOUS SYSTEM, BRAIN, PSYCHOLOGICAL, EATING, AND GASTROINTESTINAL DISORDERS; CORTICOTROPIN-RELEASING FACTOR ANTAGONISTS | PFIZER INC | 2004-07-20 | — | — | US | disclosed |
| EP-0674641-B1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0674641-A1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013676-A1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |