Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | AURKA | O14965 | 10/20 | 0.50 |
| ▸ | BRAF | P15056 | 5/20 | 0.49 |
| ▸ | RAF1 | P04049 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5494771 | 0.93 | EGFR (0.53) | EGFRKDRAURKABRAFRAF1 | |
| SCHEMBL4427451 | 0.92 | EGFR (0.52) | EGFRKDRAURKABRAF | |
| SCHEMBL5500589 | 0.92 | AURKA (0.54) | EGFRKDRAURKABRAFAURKB | |
| SCHEMBL4431208 | 0.90 | EGFR (0.53) | EGFRKDRAURKABRAF | |
| SCHEMBL4431432 | 0.82 | ADRA2A (0.47) | AURKABRAFRAF1 | |
| SCHEMBL4418947 | 0.79 | EGFR (0.60) | EGFRKDRAURKABRAFRAF1 | |
| SCHEMBL4421074 | 0.79 | KDR (0.57) | EGFRKDRAURKABRAFAURKB | |
| SCHEMBL4417552 | 0.79 | EGFR (0.59) | EGFRKDRAURKABRAF | |
| SCHEMBL4422588 | 0.78 | FLT4 (0.55) | EGFRKDRAURKABRAFRAF1 | |
| SCHEMBL4422030 | 0.76 | EGFR (0.57) | EGFRKDRAURKABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |