Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5324787 | 1.00 | KDM4E (0.55) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL1260983 | 1.00 | KDM4E (0.55) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL10935726 | 0.89 | KDM4E (0.51) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL10935721 | 0.89 | KDM4E (0.51) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL7087714 | 0.86 | SLC7A5 (0.54) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL5565921 | 0.85 | KDM4E (0.54) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL9848007 | 0.85 | KDM4E (0.54) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL30772395 | 0.85 | KDM4E (0.54) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL4551609 | 0.85 | CYP3A4 (0.51) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL38096 | 0.83 | KDM4E (0.55) | KDM4EALOX15HSD17B10ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240247034-A1 | CYSTINE KNOT SCAFFOLD PLATFORM | GENENTECH INC (US) | 2024-07-25 | — | — | US | claimed |
| US-20230174596-A1 | CYSTINE KNOT SCAFFOLD PLATFORM | GENENTECH INC (US) | 2023-06-08 | — | — | US | claimed |
| CN-114805528-A | Cystine knot scaffold platform | 豪夫迈·罗氏有限公司 | 2022-07-29 | — | — | CN | claimed |
| CN-114591422-A | Cystine knot scaffold platform | 豪夫迈·罗氏有限公司 | 2022-06-07 | — | — | CN | claimed |
| US-20200325187-A1 | CYSTINE KNOT SCAFFOLD PLATFORM | GENENTECH, INC. (US) | 2020-10-15 | — | — | US | claimed |
| US-20200231636-A1 | CYSTINE KNOT SCAFFOLD PLATFORM | GENENTECH INC (US) | 2020-07-23 | — | — | US | claimed |
| US-20180291069-A1 | CYSTINE KNOT SCAFFOLD PLATFORM | GENENTECH INC (US) | 2018-10-11 | — | — | US | claimed |
| EP-3350215-A1 | CYSTINE KNOT SCAFFOLD PLATFORM | H. Hoffnabb-La Roche Ag (CH) | 2018-07-25 | — | — | EP | claimed |
| CN-108026162-A | Cystine knot scaffold platform | 豪夫迈·罗氏有限公司 | 2018-05-11 | — | — | CN | claimed |
| US-20170129927-A1 | CYSTINE KNOT SCAFFOLD PLATFORM | GENENTECH INC (US) | 2017-05-11 | — | — | US | claimed |
| WO-2017049009-A1 | CYSTINE KNOT SCAFFOLD PLATFORM | GENENTECH, INC. (US) | 2017-03-23 | — | — | WO | claimed |
| EP-0061356-B1 | ANTAGONISTS OF THE ANTIDIURETIC AND/OR VASOPRESSOR ACTION OF ARGININE VASOPRESSIN | Medical College of Ohio (US) | 1985-07-17 | — | — | EP | claimed |
| US-4367225-A | Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin | THE MEDICAL COLLEGE OF OHIO (US) | 1983-01-04 | — | — | US | claimed |
| EP-0061356-A2 | Antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin | Medical College of Ohio (US) | 1982-09-29 | — | — | EP | claimed |
| EP-3350215-B1 | CYSTINE KNOT SCAFFOLD PLATFORM | HOFFMANN LA ROCHE (CH) | 2025-12-03 | — | — | EP | disclosed |
| CN-114591422-B | Cystine knot support platform | 豪夫迈·罗氏有限公司 | 2025-04-04 | — | — | CN | disclosed |
| CN-111405907-B | Conformationally stabilized RSV pre-fusion F proteins | 考尔德生物科技有限公司 | 2024-10-01 | — | — | CN | disclosed |
| EP-0115379-A2 | Antagonists of the antidiuretic action of arginine vasopressin | Medical College of Ohio (US) | 1984-08-08 | — | — | EP | disclosed |
| US-4367225-A | Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin | THE MEDICAL COLLEGE OF OHIO (US) | 1983-01-04 | — | — | US | disclosed |
| EP-0061356-A2 | Antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin | Medical College of Ohio (US) | 1982-09-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240247034-A1 | CYSTINE KNOT SCAFFOLD PLATFORM | LRP6, LDLR, KDR | KDM4E 3727/4885ALOX15 3884/4885HSD17B10 2819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.