Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565921 | 1.00 | KDM4E (0.54) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL5564602 | 0.94 | KDM4E (0.54) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL5566273 | 0.88 | KDM4E (0.51) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL5324787 | 0.85 | KDM4E (0.55) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL677540 | 0.85 | KDM4E (0.55) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL1260983 | 0.85 | KDM4E (0.55) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL5565685 | 0.84 | KDM4E (0.51) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL30772395 | 0.84 | KDM4E (0.54) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL19501942 | 0.82 | ALOX15 (0.57) | KDM4EALOX15HSD17B10ALDH1A1LMNA | |
| SCHEMBL15130503 | 0.82 | ALOX15 (0.57) | KDM4EALOX15HSD17B10ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451422-A1 | Pharmaceutically active fluoromethyltyrosine compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-16 | — | — | EP | claimed |
| CN-103917518-A | Simplified radiosynthesis of o-[18f]fluoromethyl tyrosine derivatives | PIRAMAL IMAGING SA | 2014-07-09 | — | — | CN | disclosed |
| CN-103857660-A | For PET imaging18Direct synthesis of F-fluoromethoxy compounds and use thereof in direct radiosynthesis of O- ([ 2 ]18F]Novel precursors of protected derivatives of fluoromethyl) tyrosine | PIRAMAL IMAGING SA | 2014-06-11 | — | — | CN | disclosed |
| EP-0451422-A1 | Pharmaceutically active fluoromethyltyrosine compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-16 | — | — | EP | disclosed |
| EP-0040150-B1 | FLUOROMETHYLATED TYROSINE METHYL ESTER | MERRELL TORAUDE ET COMPAGNIE (FR) | 1983-09-21 | — | — | EP | disclosed |
| EP-0040150-A1 | Fluoromethylated tyrosine methyl ester | MERRELL TORAUDE ET COMPAGNIE (FR) | 1981-11-18 | — | — | EP | disclosed |