Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874014 | 0.77 | EGFR (0.58) | EGFRTDO2PIK3CDPIK3CAFGFR4 | |
| SCHEMBL4233464 | 0.71 | MAPT (0.46) | EGFRTDO2 | |
| SCHEMBL9039584 | 0.70 | EGFR (0.41) | EGFRTDO2PIK3CDPIK3CAFGFR4 | |
| SCHEMBL7068666 | 0.70 | CHRNA1 (0.31) | — | |
| SCHEMBL4424448 | 0.69 | EGFR (0.43) | EGFRTDO2PIK3CDPIK3CAFGFR4 | |
| SCHEMBL3103036 | 0.68 | NQO2 (0.43) | — | |
| SCHEMBL30035692 | 0.68 | GRIN2D (0.44) | EGFRTDO2PIK3CDPIK3CA | |
| SCHEMBL6017066 | 0.68 | KDM4E (0.44) | EGFRTDO2PIK3CDPIK3CAFGFR4 | |
| SCHEMBL4431376 | 0.67 | EGFR (0.41) | EGFRTDO2PIK3CDPIK3CAFGFR4 | |
| Hydrochloric Acid SCHEMBL9229288 | 0.67 | KDM4E (0.42) | EGFRTDO2PIK3CDPIK3CAFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| EP-1218353-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca UK Limited (GB) | 2002-07-03 | — | — | EP | disclosed |
| WO-2002002534-A1 | QUINAZOLINES WITH THERAPEUTIC USE | ASTRAZENECA AB (SE) | 2002-01-10 | — | — | WO | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |
| WO-2001004102-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |