Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588479 | 0.95 | DRD2 (0.72) | DRD2HTR1AHTR6KCNH2 | |
| Oxalic Acid SCHEMBL6776746 | 0.85 | DRD2 (0.60) | DRD2HTR1A | |
| SCHEMBL6590608 | 0.84 | DRD2 (0.89) | DRD2HTR1A | |
| Oxalic Acid SCHEMBL6595691 | 0.83 | DRD2 (0.81) | DRD2HTR1AHTR6KCNH2 | |
| Oxalic Acid SCHEMBL6777204 | 0.83 | DRD2 (0.64) | DRD2HTR6KCNH2 | |
| SCHEMBL3914302 | 0.79 | DRD2 (1.00) | DRD2HTR1A | |
| SCHEMBL6590661 | 0.79 | DRD2 (0.66) | DRD2HTR1A | |
| SCHEMBL6588695 | 0.78 | DRD2 (0.78) | DRD2HTR6KCNH2 | |
| SCHEMBL6590615 | 0.78 | DRD2 (0.54) | DRD2HTR1AHTR6KCNH2 | |
| SCHEMBL6589929 | 0.77 | DRD2 (0.89) | DRD2HTR1AHTR6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1515568-A | Indole and 2,3-indoline derivative, their preparation and application | H.隆德贝克有限公司 | 2004-07-28 | — | — | CN | disclosed |
| CN-1515569-A | Indole and 2,3-indoline derivative, their preparation and application | H.隆德贝克有限公司 | 2004-07-28 | — | — | CN | disclosed |
| US-6727263-B2 | SEROTONINE REUPTAKE INHIBITOR; ANTIDEPRESSANTS; SIDE EFFECT REDUCTION | H. LUNDBECK A/S (DK) | 2004-04-27 | — | — | US | disclosed |
| CN-1127501-C | indole and 2, 3-indoline derivatives, their preparation and use | LUNDBECK & CO AS H (DK) | 2003-11-12 | — | — | CN | disclosed |
| CN-1265107-A | indole and 2, 3-indoline derivatives, their preparation and use | LUNDBECK & CO AS H (DK) | 2000-08-30 | — | — | CN | disclosed |