Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.57 |
| ▸ | PDE6C | P51160 | 6/20 | 0.57 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777087 | 1.00 | PDE5A (0.57) | PDE5APDE6CPDE11A | |
| SCHEMBL6775612 | 1.00 | PDE5A (0.57) | PDE5APDE6CPDE11A | |
| SCHEMBL6407151 | 0.87 | PDE5A (0.50) | PDE5APDE6CPDE11A | |
| SCHEMBL6773422 | 0.85 | PDE5A (0.61) | PDE5A | |
| SCHEMBL6412616 | 0.83 | PDE5A (0.53) | PDE5APDE6CPDE11A | |
| SCHEMBL6405903 | 0.83 | PDE5A (0.53) | PDE5APDE6CPDE11A | |
| SCHEMBL6412618 | 0.80 | PDE5A (0.53) | PDE5APDE6CPDE11A | |
| SCHEMBL6405906 | 0.80 | PDE5A (0.53) | PDE5APDE6CPDE11A | |
| SCHEMBL6407728 | 0.74 | PDE5A (0.83) | PDE5A | |
| SCHEMBL1891581 | 0.74 | PDE5A (0.83) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818646-B2 | 1,2,3,4-TETRAHYDRO-2-(5-(2-PYRIDINYL)-PYRIMIDIN-2-YL)-3-(2,3 -DIHYDROBENZOFURANYL)-9H-PYRROLO-(3,4-B)QUINOLIN-9-ONE; MALE ERECTILE DYSFUNCTION; SEXUAL DISORDERS | SUI ZHIHUA (US) | 2004-11-16 | — | — | US | disclosed |