Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30393282 | 0.81 | KDM4E (0.82) | KDM4EMAPTPOLBSMN1; SMN2KMT2A | |
| SCHEMBL1276481 | 0.81 | KDM4E (0.82) | KDM4EMAPTPOLBSMN1; SMN2KMT2A | |
| SCHEMBL28423933 | 0.79 | ALDH1A1 (0.50) | KDM4EMAPTRAB9AGAAALDH1A1 | |
| SCHEMBL3422999 | 0.78 | KMT2A (0.54) | KDM4EMAPTPOLBSMN1; SMN2KMT2A | |
| SCHEMBL3391812 | 0.78 | SMN1; SMN2 (0.57) | KDM4EMAPTPOLBSMN1; SMN2KMT2A | |
| SCHEMBL13038790 | 0.75 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL3424958 | 0.75 | CCNA2 (0.62) | KDM4ELMNAPOLBSMN1; SMN2KMT2A | |
| SCHEMBL178008 | 0.74 | KDM4E (0.60) | KDM4EMAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL6384249 | 0.74 | CDK2 (0.60) | KDM4EMAPTLMNAEPHX1 | |
| SCHEMBL6312356 | 0.74 | KDM4E (0.60) | KDM4EMAPTLMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138216-A1 | Process for the preparation of an essentially pure polymorph of an n-pyrazolyl-n'-naphthyl-urea | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-07-15 | — | — | US | disclosed |