Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138752 | 1.00 | SLC22A6 (0.36) | SLC22A6TP53CHRM1AKR1A1CHRM3 | |
| SCHEMBL15754776 | 0.98 | SLC22A6 (0.34) | SLC22A6TP53CHRM1AKR1A1CHRM3 | |
| SCHEMBL1138500 | 0.86 | TP53 (0.42) | TP53NFKB1FDPSCA1CA2 | |
| SCHEMBL9392661 | 0.84 | TP53 (0.41) | TP53NFKB1FDPSCA1CA2 | |
| SCHEMBL17361001 | 0.84 | TP53 (0.50) | TP53NFKB1FDPSGPR84 | |
| SCHEMBL17361029 | 0.82 | GPR84 (0.52) | TP53NFKB1FDPSGPR84 | |
| SCHEMBL8776490 | 0.82 | GPR84 (0.52) | TP53NFKB1FDPSGPR84 | |
| SCHEMBL11409643 | 0.82 | GPR84 (0.52) | TP53NFKB1FDPSGPR84 | |
| SCHEMBL17360989 | 0.82 | GPR84 (0.52) | TP53NFKB1FDPSGPR84 | |
| SCHEMBL7525608 | 0.82 | GPR84 (0.52) | TP53NFKB1FDPSGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730669-B2 | PROPHYLACTICALLY PREVENTING RETROVIRAL INFECTION OR THE SPREAD OF A RETROVIRUS, AND TREATMENT OF A RETROVIRAL INFECTION | G. D. SEARLE & CO. | 2004-05-04 | — | — | US | disclosed |
| US-20030216435-A1 | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | G. D. SEARLE & CO. | 2003-11-20 | — | — | US | disclosed |
| EP-0762880-A1 | RETROVIRAL PROTEASE INHIBITOR COMBINATIONS | G.D. SEARLE & CO. (US) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033464-A2 | RETROVIRAL PROTEASE INHIBITOR COMBINATIONS | G.D. SEARLE & CO. (US) | 1995-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216435-A1 | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | DNPEP, PREP, ANPEP | SLC22A6 2472/4885TP53 860/4885CHRM1 4863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.