Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769723 | 0.93 | EGFR (0.50) | PDGFRBPDGFRAEGFRFGFR1SYK | |
| SCHEMBL6765966 | 0.87 | PDGFRB (0.62) | PDGFRBPDGFRAEGFRFGFR1SYK | |
| SCHEMBL7077567 | 0.85 | PDGFRB (0.52) | PDGFRBPDGFRAEGFRFGFR1SYK | |
| SCHEMBL6769860 | 0.84 | SYK (0.52) | PDGFRBPDGFRAEGFRFGFR1SYK | |
| SCHEMBL6769054 | 0.83 | ROCK1 (0.54) | PDGFRBPDGFRAEGFRFGFR1SYK | |
| SCHEMBL761284 | 0.82 | SYK (0.54) | PDGFRBPDGFRAEGFRFGFR1SYK | |
| SCHEMBL6610211 | 0.81 | SYK (0.55) | PDGFRBPDGFRAEGFRSYKKDR | |
| SCHEMBL761282 | 0.81 | SYK (0.66) | PDGFRBPDGFRAEGFRFGFR1SYK | |
| SCHEMBL6770721 | 0.80 | PDGFRB (0.53) | PDGFRBPDGFRAEGFRFGFR1SYK | |
| SCHEMBL20354302 | 0.80 | SYK (0.52) | EGFRFGFR1SYKKDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762189-B1 | HEPATITIS B VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS ANTIPROLIFERATION AGENTS; REDUCED CHANCE OF TOXICITY, SIDE EFFECTS, AND DEVELOPMENT OF RESISTANT VIRAL STRAINS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2004-07-13 | — | — | US | disclosed |